A fundamental and respected resource book in critical care, The ICU Book, continues to provide the current and practical guidance that have made it the best-selling text in critical care. The text addresses... read more

Decreased mitochondrial biogenesis and dysregulated lipid oxidation contribute to compromised skeletal muscle bioenergetic status. In addition, intramuscular inflammation was associated with impaired anabolic... read more

Teleologically, the mammalian brain has evolved to be the central component of life. It coordinates afferent and efferent neural pathways, integrates neurohormonal responses and, in humans, produces higher... read more

This book describes current, evidence-based guidelines for damage control interventions across the field of trauma care with the aim of enabling clinicians to apply them to best effect in daily clinical... read more

Resuscitation teams at hospitals with high IHCA survival differ from non–top-performing hospitals. Our findings suggest core elements of successful resuscitation teams that are associated with better... read more

Supported by numerous x-rays, CT scans, plus informative tables throughout, this trusted reference begins with an informative look at kinematics and the mechanisms of trauma injury. Subsequent chapters... read more

Early application of high-volume haemofiltration (HVHF) benefits patients with severe burns, especially for those with a greater burn area (≥ 80% TBSA), decreasing the incidence of sepsis and mortality.... read more

Dr. Fraser, MD, speaks with Bruce A. Mueller, PharmD, FCCP, FASN, about his talk presented at the 47th Critical Care Congress in San Antonio, Texas, entitled “Artificial Kidney Meets Mechanical Lung:... read more

A unique question-and-answer book for surgical residents and trainees that covers all surgical aspects of critical care and acute or emergency medicine. This is a comprehensive, one-of-a-kind question-and-answer... read more

Patients with PARDS managed with lower PEEP relative to FiO2 than recommended by the ARDSNet model had higher mortality. Clinical trials targeting PEEP management in PARDS are needed. This was a multicenter,... read more

Medical errors contribute to an estimated 100,000 to 200,000 deaths per year, according to the Institute of Medicine. Burnout — defined as emotional exhaustion or depersonalization — occurs in more... read more

Elective general surgery appears to be comparably safe at any time of the workday, any day of the workweek, and in any month of the year. The binary outcomes of 32,001 elective general surgical patients... read more

Intensivists may get all the credit, but over 37,000 hospitalists provide much of the care for ICU patients in the U.S. According to a recent survey, they often do it without the presence or availability... read more

In this “Breathe Easy Critical Perspective” podcast, Dr. Dominique Pepper interviews Dr. Allan Walkey. They discuss low tidal volume ventilation in ARDS. Dr. Walkey is the chair of the Early... read more

As evidence-based guidance to aid clinicians with mechanical ventilation mode selection is scant, we sought to characterize the epidemiology thereof within a university healthcare system and hypothesized... read more

Our multifaceted, interdisciplinary approach and novel methodologic strategies can help inform the development of future critical care clinical practice guidelines. Critical illness survivors contributed... read more

The authors were tasked with developing five specific questions regarding mitochondrial function in sepsis within the context of the Acute Dialysis Quality Initiative 14 (ADQI XIV) meeting held in Bogotá,... read more

Several studies nowadays prove the physiological benefits of neurally adjusted ventilatory assist, as opposed to the conventional modes of partial support. Whether these advantages translate into improvement... read more

Flexible ICU visiting hours have the potential to reduce delirium and anxiety symptoms among patients and to improve family members’ satisfaction. However, they may be associated with an increased... read more

In patients with severe metabolic acidaemia, sodium bicarbonate had no effect on the primary composite outcome. However, sodium bicarbonate decreased the primary composite outcome and day 28 mortality... read more