Jimmy Kimmel Reveals Details of His Son’s Birth & Heart Disease

Jimmy Kimmel Reveals Details of His Son’s Birth & Heart Disease

Jimmy and his wife Molly welcomed their second child together, William "Billy" Kimmel. At three days old, Billy had successful open heart surgery at Children's Hospital Los Angeles and is now home with his family.... read more

Why Does Conflict of Interest Matter?

In this Viewpoint, the former president of the Institute of Medicine discusses the importance of conflicts of interest to the integrity of the medical profession, and the importance of policies to manage conflicts of interest... read more

Visual Aids for Infectious Disease Diagnoses

Learning the hallmarks of proper diagnosis requires using all of our senses: hearing, to listen to a patient’s symptoms; touch, to probe an infection site; and occasionally smell, to qualitatively determine infection characteristics... read more

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia

Acquired aplastic anemia results from immune-mediated destruction of bone marrow. Immunosuppressive therapies are effective, but reduced numbers of residual stem cells may limit their efficacy. In patients with aplastic anemia... read more

A Trauma Nurse Reflects On Compassion Fatigue

A Trauma Nurse Reflects On Compassion Fatigue

Kristin Laurel, a flight nurse from Waconia, Minn., has worked in trauma units for over two decades. The daily exposure to distressing situations can sometimes result in compassion fatigue. That burnout is what Laurel says... read more

Both Positive and Negative Fluid Balance May Be Associated With Reduced Long-Term Survival in the Critically Ill

Both Positive and Negative Fluid Balance May Be Associated With Reduced Long-Term Survival in the Critically Ill

Among critically ill patients with acute kidney injury, exposure to positive fluid balance, compared with negative fluid balance, has been associated with mortality and impaired renal recovery. However, it is unclear whether... read more

Antimicrobial Stewardship and Appropriate Antimicrobial Prescribing in Hospitals

Antimicrobial Stewardship and Appropriate Antimicrobial Prescribing in Hospitals

This study examines whether an antimicrobial stewardship approach grounded in behavioral theory and focusing on preserving prescriber autonomy and participation is associated with appropriateness of antimicrobial prescribing... read more

PaCO2 Equation

PaCO2 Equation

I've previously written about the alveolar gas equation and oxygen delivery equation, both of which deal with the physiologic process of oxygenation. Now I want to discuss the important relationship between alveolar... read more

New Ways for Research Findings to Reach More People

New Ways for Research Findings to Reach More People

When it comes to sharing new research findings with the world, Twitter has emerged as a key tool for scientists - and for the journals where they publish their findings. But a new study shows a way for that research to reach... read more

Implications of Prevalent Noncardiac Disease in the Cardiac ICU

Implications of Prevalent Noncardiac Disease in the Cardiac ICU

Half of >1000 patients of admitted to the cardiac intensive care unit (ICU) at a major tertiary-care center over about 1 year also had acute respiratory failure, acute kidney injury, or sepsis. Those with lung or kidney... read more

Strategies for Optimizing Diagnostic Predictive Value of Clostridium difficile

Strategies for Optimizing Diagnostic Predictive Value of Clostridium difficile

Because nucleic acid amplification tests (NAATs) do not distinguish Clostridium difficile infection (CDI) and asymptomatic C. difficile carriage, the diagnostic predictive value of NAATs is limited when used in patients with... read more

New Study: Economic Cost to Surviving ARDS

New Study: Economic Cost to Surviving ARDS

Research published today in the American Journal of Respiratory and Critical Care Medicine sheds light on the economic toll on survivors of acute respiratory distress syndrome. Nearly 50% of survivors who worked before they... read more

Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents

Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents

Multidrug-resistant gram-negative bacteria (MDR-GNB) are associated with an increasing proportion of infections among nursing home (NH) residents. The objective of this systematic review and meta-analysis was to critically... read more

Viral coinfection is shaped by host ecology and virus-virus interactions across diverse microbial taxa and environments

Infection of more than one virus in a host, coinfection, is common across taxa and environments. Viral coinfection can enable genetic exchange, alter the dynamics of infections, and change the course of viral evolution. Yet,... read more

Michael Lewis’ The Undoing Project: How do ER surgeons avoid dumb, deadly mistakes? Ask their doctor

Michael Lewis’ The Undoing Project: How do ER surgeons avoid dumb, deadly mistakes? Ask their doctor

In an excerpt from his new book Michael Lewis examines a Toronto doctor who helps trauma surgeons avoid errors in judgment when life and death are on the line. Doctors tended to see only what they were trained to see: That... read more

I was confident in my patient’s care. Then my senior doctor overruled me

I was confident in my patient’s care. Then my senior doctor overruled me

When a resident and an attending physician disagree, the attending has the right to overrule the resident. But both should talk openly about the issue. During one 28-hour call shift, I took care of a critically ill man in... read more

Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients

Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients

Objectives: To prospectively validate that the inability to decrease procalcitonin levels by more than 80% between baseline and day 4 is associated with increased 28-day all-cause mortality in a large sepsis patient population... read more