Tag: antimicrobial
New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections
Only few new molecules have an adequate activity against MDR gram-negative pathogens, especially carbapenemase-producer strains. Among these, ceftozolane/tazobactam has been recently approved for clinical use. Other compounds,... read more
Understanding Central Nervous System Efficacy of Antimicrobials
Defining the optimal treatment of Central Nervous System (CNS) infections is one of the most challenging tasks for the intensivists; the therapeutic window is narrow, and the alternative drug options more limited than with... read more
I Contain Multitudes: The Microbes Within Us and a Grander View of Life
Joining the ranks of popular science classics like The Botany of Desire and The Selfish Gene, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since... read more
Addressing Antimicrobial Resistance and Stewardship
Antimicrobial-resistant infections affect more than 2 million people annually in the United States alone, accounting for an estimated 23 000 deaths and estimated economic costs of $55 billion. Recent projections suggest... read more
New Biomarker Improves Early Sepsis Detection in the Emergency Department
Sepsis most often presents to the emergency department (ED), and delayed detection is harmful. The white blood count (WBC) is often used to detect sepsis in the ED. New research shows that volume increases of circulating... read more
Evaluation of early antimicrobial therapy adaptation guided by the BetaLACTA test
Rapid diagnostic tests detecting microbial resistance are needed for limiting the duration of inappropriateness of empirical antimicrobial therapy (EAT) in ICU patients, besides reducing the use of broad-spectrum antibiotics.... read more
