Circulating Secretoneurin Concentrations After Cardiac Surgery

Circulating Secretoneurin Concentrations After Cardiac Surgery

Circulating postoperative secretoneurin concentrations provide incremental prognostic information to established risk indices in patients undergoing cardiac surgery. Preoperative and postoperative secretoneurin concentration... read more

Early Neuromuscular Blockade in the ARDS

Early Neuromuscular Blockade in the ARDS

Among patients with moderate-to-severe ARDS who were treated with a strategy involving a high PEEP, there was no significant difference in mortality at 90 days between patients who received an early and continuous cisatracurium... read more

Critical Illness and Cardiac Dysfunction in Anthracycline-Exposed Pediatric Oncology Patients

Critical Illness and Cardiac Dysfunction in Anthracycline-Exposed Pediatric Oncology Patients

Children with cancer who received anthracyclines, especially at higher doses, and who develop cardiac dysfunction are at higher risk of critical illness, have higher rates of multiple organ dysfunction and higher rates of... read more

Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients

Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients

In isolation of other medication, a hemodynamic response to IV acetaminophen has a higher prevalence in critically ill children with cardiac disease than previously thought and justifies controlled studies in the perioperative... read more

Validation and Critical Evaluation of the Effective Arterial Elastance in Critically Ill Patients

Validation and Critical Evaluation of the Effective Arterial Elastance in Critically Ill Patients

In critically ill patients, effective arterial elastance may be reliably estimated at bedside. We support the use of this validated estimate of effective arterial elastance when coupled with an index of left ventricular contractility... read more

Level and Prevalence of Spin in Published Cardiovascular Randomized Clinical Trial Reports With Statistically Nonsignificant Primary Outcomes

Level and Prevalence of Spin in Published Cardiovascular Randomized Clinical Trial Reports With Statistically Nonsignificant Primary Outcomes

In this systematic review that included 93 reports of Randomized Clinical Trials (RCTs) from 6 high-impact journals, positive spin of statistically nonsignificant primary outcomes was found in 57% of abstracts and 67% of... read more

In-Hospital Cardiac Arrest

In-Hospital Cardiac Arrest

In-hospital cardiac arrest is common and associated with a high mortality rate. Despite this, in-hospital cardiac arrest has received little attention compared with other high-risk cardiovascular conditions, such as stroke,... read more

ECMO Global Trends and Use in Cardiopulmonary Resuscitation

ECMO Global Trends and Use in Cardiopulmonary Resuscitation

In this video, Dr. Ravi Thiagarajan, Chief of the Division of Cardiac Critical Care at Boston Children's Hospital, and Professor of Pediatrics at Harvard Medical School, outlines past and present trends in ECMO use across... read more

This Minimally Invasive Technique Could Reduce the Need for Open-Heart Surgery

This Minimally Invasive Technique Could Reduce the Need for Open-Heart Surgery

Currently, the majority of individuals who undergo transcather aortic valve replacement (TAVR), a minimally invasive alternative to open-heart surgery—are elderly or subject to compounding complications such as kidney disease.... read more

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality

Among US adults, higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident cardiovascular disease (CVD) and all-cause mortality in a dose-response manner. 29,615 adults pooled... read more

Predicting the Haemodynamic Response to Prone Positioning

Predicting the Haemodynamic Response to Prone Positioning

A Novel and Simultaneous Analysis of the Guyton and Rahn Diagrams. Graphical models of physiology are heuristically appealing as they facilitate qualitative conclusions at the bedside of the critically ill. Historically,... read more

Cast of the Right Bronchial Tree

Cast of the Right Bronchial Tree

A 36-year-old man was admitted to the intensive care unit with an acute exacerbation of chronic heart failure. His medical history included heart failure with an ejection fraction of 20%, bioprosthetic aortic-valve replacement... read more

Medical Device Rules Need Drastic Change To Protect Patients

Medical Device Rules Need Drastic Change To Protect Patients

Urgent and drastic changes to the rules around medical devices, such as pacemakers, are needed to protect patients, according to the Royal College of Surgeons. It wants a register of every device in every patient set up so... read more

“Real-World” Application of Thrombolysis in Cardiac Arrest

“Real-World” Application of Thrombolysis in Cardiac Arrest

In a single center's experience, thrombolytic therapy is used infrequently for the management of cardiac arrest. Thrombolysis during cardiac arrest should be considered on a case-by-case basis and should be utilized only... read more