Diagnosis of Sepsis from a Drop of Blood by Measurement of Spontaneous Neutrophil Motility in a Microfluidic Assay

Current methods for the diagnosis of sepsis have insufficient precision, causing regular misdiagnoses. Microbiological tests can help to diagnose sepsis, but are usually too slow to have an impact on timely clinical decision-making.... read more

Diagnosis of Sepsis from a Drop of Blood by Measurement of Spontaneous Neutrophil Motility in a Microfluidic Assay

Reducing contamination rates in urine samples

Contamination is thought to be a significant problem. Depending on which study you look at, the rates of urine contamination can be 17% or upwards. The standard method of midstream urine collection is for the healthcare professional... read more

Reducing contamination rates in urine samples

Severe Sepsis Care in the Emergency Department

Drs. John C. Perkins and Michael E. Winters have assembled an expert team of authors on the topic of Sepsis in the Emergency Department. Article topics include: Defining and Diagnosing Sepsis; Appropriate Antibiotic Therapy;... read more

Severe Sepsis Care in the Emergency Department

Fluid, Electrolyte and Acid-Base Physiology

With a strong focus on problem solving and clinical decision making, Fluid, Electrolyte, and Acid-Base Physiology is your comprehensive, go-to guide on the diagnosis and management of fluid, electrolytes, and acid-base disorders.... read more

Fluid, Electrolyte and Acid-Base Physiology

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis

Many sepsis survivors develop chronic critical illness (CCI) and are assumed to be immunosuppressed, but there is limited clinical evidence to support this. We sought to determine whether the incidence of secondary infections... read more

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis

The Right Tool for the Right Patient

Resuscitative TEE in the diagnosis of massive PE in the ED. We have multiple tools in the ed that allow us to assess patients rapidly. But of course, you must use the right tool for the patient. transthoracic echo (TTE) can... read more

The Right Tool for the Right Patient

The long sepsis journey in low- and middle-income countries begins with a first step… but on which road?

Infection and sepsis are among the most frequent acute medical conditions worldwide and result in approximately eight million premature deaths each year, most of which occur in low and lower-middle income countries (LMICs).... read more

The long sepsis journey in low- and middle-income countries begins with a first step… but on which road?

The Randomized Educational ARDS Diagnosis Study

Radiographic criteria for acute respiratory distress syndrome have been criticized for poor reliability. Our objective was to test an educational intervention to improve the radiographic identification of acute respiratory... read more

The Randomized Educational ARDS Diagnosis Study

Research Aims to Fine-Tune Sepsis Diagnosis

Work designed to improve diagnosis of one of the leading causes of death in children is under way in Brisbane, led by a University of Queensland researcher. Mater Research Institute-UQ Associate Professor Luregn Schlapbach... read more

Research Aims to Fine-Tune Sepsis Diagnosis

Distributions and Behavior of Vital Signs in Critically Ill Children by Admission Diagnosis

This is the first study reporting distributions of continuously measured physiologic variables and trends in their behavior according to admission diagnosis in critically ill children. Differences detected between and within... read more

Distributions and Behavior of Vital Signs in Critically Ill Children by Admission Diagnosis

The Sound of Air: Point-of-Care Lung Ultrasound in Perioperative Medicine

Lung ultrasound (LUS) has emerged as an effective and accurate goal-directed diagnostic tool that can be applied in real time for the bedside assessment of patients with respiratory symptoms and signs. Lung ultrasound has... read more

The Sound of Air: Point-of-Care Lung Ultrasound in Perioperative Medicine

Prognostic Effects of Delirium Motor Subtypes in Hospitalized Older Adults

One in three acutely ill hospitalized older adults who suffered hypo-active or mixed delirium died in the hospital. Clinicians should be aware that hypo-active symptoms of delirium, whether shown exclusively or in alternation... read more

Prognostic Effects of Delirium Motor Subtypes in Hospitalized Older Adults

Differential Diagnosis Between Newly Diagnosed Asthma and COPD Using EBC Metabolomics

Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with high pathological burden and healthcare costs. In the outpatient clinical practice, an accurate differential diagnosis is often very... read more

Differential Diagnosis Between Newly Diagnosed Asthma and COPD Using EBC Metabolomics

Vascular Access in Critically Ill Pediatric Patients With Obesity

Severe obesity is associated with decreased overall likelihood of placement of a vascular access device but increased likelihood of peripherally inserted central catheter placement and of device-related complications. Patients... read more

Vascular Access in Critically Ill Pediatric Patients With Obesity

Machine Learning Model Predicts Sepsis in ICU Patients 12 Hours Before Diagnosis

A machine learning model accurately predicted the onset of sepsis in ICU patients four to 12 hours prior to clinical recognition in a recent study. The observational cohort study used data from more than 31,000 admissions... read more

Machine Learning Model Predicts Sepsis in ICU Patients 12 Hours Before Diagnosis

Six-month Outcome of Immunocompromised Severe ARDS Patients Rescued by ECMO

Recently diagnosed immunodeficiency is associated with a much better prognosis in ECMO-treated severe ARDS. However, low 6-month survival of our large cohort of immunocompromised patients supports restricting ECMO to patients... read more

Six-month Outcome of Immunocompromised Severe ARDS Patients Rescued by ECMO

The role of serum amyloid A staining of granulomatous tissues for the diagnosis of sarcoidosis

Previous studies demonstrated that SAA staining of sarcoidosis granulomas was qualitatively and quantitatively different from other granulomatous diseases. These data suggest that positive SAA staining of granulomatous tissue... read more

The role of serum amyloid A staining of granulomatous tissues for the diagnosis of sarcoidosis