Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis

We conclude that antibiotic therapy is highly time sensitive, and efforts should be made to deliver this critical therapy as early as possible in sepsis, perhaps extending into the first point of medical contact outside the... read more

Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis

Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation

Delirium in critically ill patients is associated with poor clinical outcomes. Neuroinflammation might be an important mechanism in the pathogenesis of delirium, and since simvastatin has anti-inflammatory properties it might... read more

Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes

Critically ill patients have low vitamin C concentrations despite receiving standard ICU nutrition. Septic shock patients have significantly depleted vitamin C levels compared with non-septic patients, likely resulting from... read more

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes

Optimal Approach to Mechanical Ventilation After Cardiac Arrest

Return of spontaneous circulation after cardiac arrest results in a systemic inflammatory state called the post-cardiac arrest syndrome (PCAS), characterised by oxidative stress, coagulopathy, neuronal injury, and organ dysfunction.... read more

Optimal Approach to Mechanical Ventilation After Cardiac Arrest

Dr. Paul Wischmeyer Brings Humanity To Medicine

Dr. Paul Wischmeyer's journey to becoming an internationally-renowned critical care and perioperative nutrition researcher and clinician began at the age of 15 when a bout of strep throat and a prescription for antibiotics... read more

Dr. Paul Wischmeyer Brings Humanity To Medicine

Platelets and Multi-Organ Failure in Sepsis

Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more... read more

Platelets and Multi-Organ Failure in Sepsis

Adverse Effects of Crystalloid and Colloid Fluids

Volume therapy can be managed according to the fluid balance method, the outcome-guided method, or the goal-directed method. One reason why fluid is needed is that anesthesia disrupts the normal autonomic control of the circulation,... read more

Adverse Effects of Crystalloid and Colloid Fluids

Cellular Immunotherapy for Septic Shock

The infusion of freshly cultured allogenic bone marrow derived MSCs into participants with septic shock up to a dose of 3 million cells per kg (250 million cells) appears safe. Ages of participants in the interventional versus... read more

Cellular Immunotherapy for Septic Shock

Metformin and Aspirin Potential Key in Treating Inflammatory Diseases

Ingredient in aspirin combined with popular diabetes drug can turn off faulty protein that plays a key role in inflammatory diseases, such as rheumatoid arthritis. ... read more

Metformin and Aspirin Potential Key in Treating Inflammatory Diseases

Drink Coffee and Live Longer: Cohort Study

A multinational cohort study on coffee drinking and mortality in 10 European countries. Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country. 521, 330 people... read more

Drink Coffee and Live Longer: Cohort Study

New Institute to Focus on Immune System

Vanderbilt University Medical Center (VUMC) is launching a new institute to coordinate initiatives among the rapidly evolving disciplines of infection biology, immunology and inflammatory diseases. The Vanderbilt Institute... read more

New Institute to Focus on Immune System

Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study

Sevoflurane improves gas exchange, and reduces alveolar edema and inflammation in preclinical studies of lung injury, but its therapeutic effects have never been investigated in acute respiratory distress syndrome (ARDS).... read more

Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study

Lung Microbiome: Key to Respiratory Ills?

Recently, JAMA discussed this research and its potential clinical applications with 2 experts on the front lines, Jack Gilbert, PhD, a microbial ecologist at the University of Chicago and director of its new Microbiome Center... read more

Lung Microbiome: Key to Respiratory Ills?

The Prevalence of Acute Critical Neurological Disease in Children

Neurologic insults are a significant pediatric international health issue. They are frequent and contribute substantial morbidity and mortality. These data suggest a need for an increased focus on acute critical neurologic... read more

The Prevalence of Acute Critical Neurological Disease in Children

Doctor Turns Up Possible Treatment For Deadly Sepsis

It is hard not to get excited about news of a potentially effective treatment for sepsis, a condition that leads to multiple organ failure and kills more people in the hospital than any other disease. The study, from Eastern... read more

Doctor Turns Up Possible Treatment For Deadly Sepsis

Decreased cytokine production by mononuclear cells after severe gram-negative infections

Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood. Defective TNF-α production... read more

Decreased cytokine production by mononuclear cells after severe gram-negative infections

New Guidelines for Accurate Diagnosis of C. difficile Infection

Clostridium difficile infection (CDI), a potentially lethal bacterial infection, causes colon inflammation and is responsible for 3,700 deaths in Europe per year. This highly symptomatic infection causes fever, diarrhea,... read more

New Guidelines for Accurate Diagnosis of C. difficile Infection