Contrast-Induced Nephropathy: Confounding Causation

Contrast-Induced Nephropathy: Confounding Causation

Comparing the methodological rigor of more recent CIN studies to those in the past, it seems clear that earlier studies purporting a causal relationship between AKI and contrast administration were only identifying an association... read more

Epstein-Barr risk increased by Immune Molecule Deficiency

Epstein-Barr risk increased by Immune Molecule Deficiency

Researchers from the National Institutes of Health National Institute of Allergy and Infectious Diseases, or NIAID, have found a genetic immune disorder causing increased risk and poor control of Epstein-Barr virus and EBV-associated... read more

Reducing Natalizumab Concentration May Reduce PML Risk

Reducing Natalizumab Concentration May Reduce PML Risk

Serum concentrations of natalizumab do not appear to rise before patients with relapsing-remitting multiple sclerosis are diagnosed with progressive multifocal leukoencephalopathy, contradicting the hypothesis that exposure... read more

Plazomicin Succeeds in Phase 3 cUTI and CRE Trial

Plazomicin Succeeds in Phase 3 cUTI and CRE Trial

Plazomicin an antibiotic being developed to fight multidrug-resistant bacterial infections, has met the primary objective of noninferiority compared with meropenem in a phase 3 registration trial among patients with complicated... read more

Guidelines for Neuromuscular Blockade in the Adult Critically Ill Patient

Guidelines for Neuromuscular Blockade in the Adult Critically Ill Patient

The Society of Critical Care Medicine recently released guidelines addressing sustained neuromuscular blockade in the adult critically ill patient.... read more

Beta-Lactam Infusion in Severe Sepsis (BLISS)

Beta-Lactam Infusion in Severe Sepsis (BLISS)

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.... read more