Tag: inhibitors
Data from clinical registries can ID novel drug interactions
Data mining can be used to discover unknown drug-drug interactions in cardiovascular medicine, according to a study published online Nov. 8 in Circulation: Cardiovascular Quality and Outcomes.... read more
Cellular Mechanisms of Prevention of Ischemia-Reperfusion Injury
Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult.... read more
Impaired recycling of mitochondria in autism?
The new study shows that autophagy is defective in TSC. The scientists further showed that two existing classes of drugs counter the defect: the epilepsy drug carbamazepine, and drugs known as mTOR inhibitors.... read more
HDAC inhibitors show promise against cancer stem cells
A group of researchers, led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has shown that histone deacetylase (HDAC) inhibitors have the potential to eliminate... read more
Bifunctional drug could treat tumors resistant to current mTOR inhibitors
The first known bifunctional inhibitor for the mechanistic target of rapamycin (mTOR) protein was developed to overcome current known mechanisms of tumor resistance to mTOR inhibitors.... read more
