A Multicentre Randomised Controlled Trial of Levetiracetam vs. Phenytoin for Convulsive Status Epilepticus in Children

A Multicentre Randomised Controlled Trial of Levetiracetam vs. Phenytoin for Convulsive Status Epilepticus in Children

Convulsive status epilepticus (CSE) is the most common life-threatening childhood neurological emergency. Despite this, there is a lack of high quality evidence supporting medication use after first line benzodiazepines,... read more

Travel Times Affect Neurocritical Care Unit Nurse Staffing Levels

Travel Times Affect Neurocritical Care Unit Nurse Staffing Levels

For specialist nurses on neurocritical care units, accompanying patients for imaging scans and other procedures has a major impact on nurse staffing ratios, reports a study in the Journal of Neuroscience Nursing. Over 30... read more

Ultrasound Non-invasive Measurement of Intracranial Pressure in Neurointensive Care

Ultrasound Non-invasive Measurement of Intracranial Pressure in Neurointensive Care

Of the studied ultrasound nICP methods, ONSD is the best estimator of Intracranial Pressure (ICP). The novel combination of ONSD ultrasonography and vTCD of the straight sinus is a promising and easily available technique... read more

Cryptococcus Neoformans Meningoencephalitis

Cryptococcus Neoformans Meningoencephalitis

A 36-year-old man presented to the emergency department with a 2-week history of fever, headache, drowsiness, and photophobia. He was previously healthy and was sexually active with men. The physical examination was notable... read more

When the Air Hits Your Brain: Tales from Neurosurgery

When the Air Hits Your Brain: Tales from Neurosurgery

With poignant insight and humor, Frank Vertosick Jr., MD, describes some of the greatest challenges of his career, including a six-week-old infant with a tumor in her brain, a young man struck down in his prime by paraplegia,... read more

Efficacy of Combined Intravenous Thrombolysis and Thrombectomy

Efficacy of Combined Intravenous Thrombolysis and Thrombectomy

Mechanical thrombectomy (MT) improves clinical outcomes in patients with acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known whether intravenous thrombolysis (IVT) is of added benefit... read more

Combined Intravenous Thrombolysis and Thrombectomy vs Thrombectomy Alone for Acute Ischemic Stroke

Combined Intravenous Thrombolysis and Thrombectomy vs Thrombectomy Alone for Acute Ischemic Stroke

The results indicate that treatment of patients experiencing AIS due to a large vessel occlusion with IVT before MT does not appear to provide a clinical benefit over MT alone. A randomized clinical trial seems warranted.... read more

Model Identifies Seizure Risk in Critically Ill

Model Identifies Seizure Risk in Critically Ill

For critically ill patients, a model comprising six variables can identify the probability of seizure, according to a study published online Oct. 9 in JAMA Neurology. Aaron F. Struck, M.D., from the University of Wisconsin... read more

Development and Validation of an Empiric Tool to Predict Favorable Neurologic Outcomes Among PICU Patients

Development and Validation of an Empiric Tool to Predict Favorable Neurologic Outcomes Among PICU Patients

This proposed prediction tool encompasses 20 risk factors into one probability to predict favorable neurologic outcome during ICU stay among children with critical illness. Future studies should seek external validation and... read more

Do No Harm: Stories of Life, Death, and Brain Surgery

Do No Harm: Stories of Life, Death, and Brain Surgery

With astonishing compassion and candor, leading neurosurgeon Henry Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets and the moments of black humor that... read more

Coma with Eelco Wijdicks – Podcast

So you have an unresponsive patient. The CT is negative. What now? Coma is tough! The differential is long and filled with many life threats.... read more