Microcirculation Evolution in Patients on VA-ECMO for Refractory Cardiogenic Shock

Microcirculation Evolution in Patients on VA-ECMO for Refractory Cardiogenic Shock

Microcirculation is severely impaired in patients with refractory cardiogenic shock requiring venoarterial extracorporeal membrane oxygenation (VA-ECMO). Inability to rapidly restore microcirculation during the first... read more

Impaired Cerebral Auto-regulation is Associated with Brain Dysfunction in Patients with Sepsis

Impaired Cerebral Auto-regulation is Associated with Brain Dysfunction in Patients with Sepsis

Cerebral auto-regulation was altered in half of the patients with sepsis and was associated with the development of SABD. These findings support the concept that cerebral hypoxia could contribute to the development of... read more

Apneic Oxygenation As a Quality Improvement Intervention in an Academic PICU

Apneic Oxygenation As a Quality Improvement Intervention in an Academic PICU

Implementation of apneic oxygenation in PICU was feasible, and was associated with significant reduction in moderate and severe oxygen desaturation. Use of apneic oxygenation should be considered when intubating critically... read more

Mechanical Ventilation in Patients with Acute Ischemic Stroke

Mechanical Ventilation in Patients with Acute Ischemic Stroke

Although there are no specific data regarding the effect of respiratory management on stroke patients' outcomes, specific ventilator strategies in this population could potentially improve neurologic outcome and prevent respiratory... read more

Outcomes of VV ECMO When Stratified by Age

Outcomes of VV ECMO When Stratified by Age

The purpose of this study was to evaluate survival to hospital discharge for patients on venovenous extracorporeal membrane oxygenation (VV ECMO) when stratified by age. We performed a retrospective study at single, academic,... read more

FDA Approves New Pill to Treat Sickle Cell Disease

FDA Approves New Pill to Treat Sickle Cell Disease

The Food and Drug Administration on Monday approved a once-daily pill for sickle cell disease that works in an entirely new way — by boosting hemoglobin, the oxygen-carrying molecule found in red blood cells. The novel... read more

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

In adults undergoing mechanical ventilation in the ICU, the use of conservative oxygen therapy, as compared with usual oxygen therapy, did not significantly affect the number of ventilator-free days. The number of ventilator-free... read more

Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock

Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock

Temporary circulatory support (TCS) have become the cornerstone of the management of patients with cardiogenic shock, although the evidence supporting their efficacy is limited. VA-ECMO is considered the first-line option,... read more

ECMO in Out-of-Hospital Cardiac Arrest

ECMO in Out-of-Hospital Cardiac Arrest

In a population-based registry, 4% of out-of-hospital cardiac arrests (OHCA) were treated with extracorporeal-CPR, which was not associated with increased hospital survival. Early extracorporeal membrane oxygenation (ECMO)... read more

Transport of a Prone Position ARDS Patient

Transport of a Prone Position ARDS Patient

Critical care transport of prone acute respiratory distress syndrome (ARDS) patients is a feasible and cost-effective intervention that will help prevent treatment delays and interruptions. A nonphysician critical care... read more

Is Hemoglobin Good for Cerebral Oxygenation and Clinical Outcome in Acute Brain Injury?

Is Hemoglobin Good for Cerebral Oxygenation and Clinical Outcome in Acute Brain Injury?

Hemoglobin is important for cerebral oxygenation and strategies to minimize anemia should be undertaken. higher hemoglobin levels are associated with less cerebral ischemia and better clinical outcome, whether this remains... read more

Development and Assessment of Objective Surveillance Definitions for Nonventilator Hospital-Acquired Pneumonia

Development and Assessment of Objective Surveillance Definitions for Nonventilator Hospital-Acquired Pneumonia

These findings suggest that objective surveillance for NV-HAP using electronically computable definitions that incorporate common clinical criteria is feasible and generates incidence, mortality, and adjusted ORs for hospital... read more

Management of Peripheral Venoarterial ECMO in Cardiogenic Shock

Management of Peripheral Venoarterial ECMO in Cardiogenic Shock

Extracorporeal membrane oxygenation (ECMO) is a powerful mechanical circulatory support modality capable of rapidly restoring systemic perfusion yet lacking in defined approaches to management. Adopting a management approach... read more

Epinephrine, Inodilator, or No Inotrope in VA-ECMO Implantation

Epinephrine, Inodilator, or No Inotrope in VA-ECMO Implantation

Early epinephrine therapy within the first 24 h after cannulation for venoarterial extracorporeal membrane oxygenation (VA-ECMO) was associated with poor survival compared to patients with or without any inodilator therapy.... read more

Oxygen Treatment in Intensive Care and Emergency Medicine

Oxygen Treatment in Intensive Care and Emergency Medicine

Hypoxemia should certainly be avoided, but the fact that the liberal administration of oxygen to patients in intensive care units and emergency rooms tends to increase morbidity and mortality implies the advisability of a... read more

Platelet Function During ECMO in Adult Patients

Platelet Function During ECMO in Adult Patients

Employing impedance aggregometry and flow cytometry, we found both impaired platelet aggregation and decreased platelet activation on day 1 of Extracorporeal Membrane Oxygenation (ECMO) support compared with healthy controls.... read more

Lung Recruitability in Severe ARDS Requiring ECMO

Lung Recruitability in Severe ARDS Requiring ECMO

Significant variability in potential for lung recruitment in patients with severe acute respiratory distress syndrome (ARDS) requiring extracorporeal membrane oxygenation (ECMO). 47 adults with severe ARDS requiring ECMO... read more