Steroids in Septic Shock – Four Misconceptions and One Truth

The utility of steroids in sepsis has been debated passionately for decades. There is hope that steroids might improve mortality, but also fear that they could increase infectious complications. Practice varies widely. What... read more

Metabolic Sepsis Resuscitation

There are roughly two strategies for adjusting the intensity of treatment: Titrated strategy: Treatment intensity is adjusted to match the severity of the disease. Escalation-deescalation strategy: Treatment intensity is... read more

Vitamin Treatment For Sepsis Is Put To The Test

Dr. Jonathan Sevransky was intrigued when he heard that a well-known physician in Virginia had reported remarkable results from a simple treatment for sepsis. Could the leading cause of death in hospitals really be treated... read more

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

The use of steroids in critically ill patients continues to be controversial. Whilst there are signals for improved cardiovascular parameters, this did not translate to clear mortality benefits. The most recent of these trials... read more

Can A Cocktail Of Vitamins And Steroids Cure A Major Killer In Hospitals?

Scientists have launched two large studies to test a medical treatment that, if proven effective, could have an enormous impact on the leading cause of death in American hospitals. The treatment is aimed at sepsis, a condition... read more

Human limb skeletal muscle wasting and architectural remodeling during five to ten days intubation and ventilation in critical care

Using ultrasound, we have been able to demonstrate that muscle thickness and architecture of vastus lateralis undergo rapid changes during the early phase of admission to a critical care environment. Muscle loss in critically... read more

Steroids for severe CAP. Should I?

Steroids. I always have mixed feelings about them. It's a Love & Hate relationship inside my head. On one hand I cannot stand those who claim steroids are the critical care's Holy Grail. Steroids for sepsis, ARDS, trauma,... read more

Non-invasive Respiratory Support and Methylxanthines Reduce Re-Intubations

In a meta-analysis of randomized studies evaluating efforts to reduce re-intubations and respiratory failure in preterm infants, non-invasive respiratory support and use of methylxanthines (theophylline, caffeine) were found... read more

1-Hour AMI Rule; Early Steroids in Kawasaki Disease; The Gut in PAD

Sensitivity of the European Society of Cardiology's 1-hour algorithm for assessing acute MI with high-sensitivity cardiac troponin may be insufficient for some ED physicians to confidently send patients home.... read more