Tag: study
Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound
Cationic antimicrobial peptides are multifunctional molecules that have a high potential as therapeutic agents. We have identified a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. Using... read more
Communicating Context in Quality Improvement Reports
The study by Demb and colleagues reports on the positive results of an intervention strategy to reduce excess radiation exposure across 5 academic medical centers associated with the University of California. Leading up to... read more
The impact of emergency department crowding on early interventions and mortality in patients with severe sepsis
Critically ill patients require significant time and care coordination in the emergency department (ED). We hypothesized that ED crowding would delay time to intravenous fluids and antibiotics, decrease utilization of protocolized... read more
Value-Based Reforms and the Hospital Readmission Reduction Program
In this longitudinal study of 2837 US hospitals between 2008 and 2015, we found that participation in 1 or more Medicare value-based reforms - including the Meaningful Use of Electronic Health Records program, the Accountable... read more
The Prevalence of Acute Critical Neurological Disease in Children
Neurologic insults are a significant pediatric international health issue. They are frequent and contribute substantial morbidity and mortality. These data suggest a need for an increased focus on acute critical neurologic... read more
The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU
Poor sleep is common in the ICU setting and may represent a modifiable risk factor for patient participation in ICU-based physical therapy (PT) interventions. This study evaluates the association of perceived sleep quality,... read more
Association between delirium superimposed on dementia and mortality in hospitalized older adults
In a prospective cohort study, Thiago Junqueira Avelino-Silva and colleagues examine the association of delirium superimposed on dementia on hospital mortality and 12-month mortality in hospitalized older adults. This was... read more
Resistance Training for Glycemic Control, Muscular Strength, and Lean Body Mass in Old Type 2 Diabetic Patients
Type 2 diabetes (T2D) in elderly patients is associated with accelerated loss of skeletal muscle mass and strength. However, there are few meta-analysis reviews which investigate the effects of resistance training (RT) on... read more
A Call for Fresh Airway Management Standards
Anesthesiology News recently reported on a study that promoted the LMA in prone position to "avoid intubation, reduce use of relaxants and minimize airway trauma." This study reflects increasing confusion in a complex... read more
Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation
Fluid loading is usually the first step in the resuscitation of patients with acute circulatory failure. Fluid responsiveness is defined as the ability of the left ventricle to increase its stroke volume in response to fluid... read more
Relative Bradycardia in Patients With Septic Shock Requiring
Relative bradycardia in patients with septic shock is associated with lower mortality, even after adjustment for confounding. Our data support expanded investigation into whether inducing relative bradycardia will benefit... read more
Pre-hospital therapeutic hypothermia: The RINSE trial
Therapeutic hypothermia has had a bit of a rollercoaster ride over the last few years. It was all the rage following three small trials, which initially suggested a significant benefit from cooling patients to 33C following... read more
Intraoperative Oxidative Stress Associated With Postoperative Delirium
Intraoperative oxidative stress is associated with postoperative delirium in ICU patients after cardiac surgery, a study has found. Researchers from Vanderbilt University Medical Center, in Nashville, Tenn., came to this... read more
2017’s Tell-All Social Media Guide for Doctors and Hospitals
You may have thought "this too shall pass", but now you’ve realized the inevitable truth: social media is here to stay. If you’ve never given social media much thought when it comes to your physician practice... read more
ICU Study Shows Significant Reduction in Time to Blood Gas Result using Sphere Medical’s Proxima
A recent time and motion study by University Hospital Southampton demonstrated a 1.5 minute (>20%) reduction in time to blood gas results when using the Proxima bedside blood gas monitoring system. The study also found... read more
Early, Goal-Directed Therapy for Septic Shock
After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This... read more
How to keep up with the scientific literature
Few aspects of scientific work may be as crucial - and yet as easy to neglect - as reading the literature. Beginning a new research project or writing a grant application can be good opportunities for extensive literature... read more
