Sepsis Algorithm a Deadly Marker

Sepsis Algorithm a Deadly Marker

An attempt by a Phoenix, AZ, hospital to develop a marker for deadly sepsis instead found that the algorithm identified patients at an increased risk of dying. Increasingly, algorithms govern daily life, playing an important... read more

Poor outcome predictors in status epilepticus

Poor outcome predictors in status epilepticus

Predictors of poor outcomes in patients with status epilepticus admitted to the neurointensive care unit include complex partial status epilepticus, refractory status epilepticus, or the development of nonconvulsive status... read more

First ICU for Men Suffering from Cold

First ICU for Men Suffering from Cold

There's finally hope for the critically ill! The Münster University Hospital has set up an intensive care unit exclusively for the treatment of male patients suffering from coughs, colds, or even both. A specially trained... read more

Hospital ICUs Are Overused

Hospital ICUs Are Overused

A study conducted on ICU admissions at Harbor-UCLA Medical Center states that the hospital’s Intensive Care Units are being overused by non-deserving patients. This revelation is suggesting that the hospital’s most evasive... read more

In-Bed Cycling Feasible for ICU Patients on Ventilation

In-Bed Cycling Feasible for ICU Patients on Ventilation

TryCYCLE was the first study in the CYCLE research program. In TryCYCLE, we determined it was safe and feasible to bike with mechanically ventilated medical surgical patients very early in their ICU stay.... read more

Metformin Associated with Reduced Mortality in CKD, CHF, and CLD

Metformin Associated with Reduced Mortality in CKD, CHF, and CLD

Metformin is currently the suggested initial treatment for type 2 diabetes mellitus in the United States. In the past, the U.S. Food and Drug Administration (FDA) did not recommend metformin for patients with chronic kidney... read more

PERTs Aim to Disentangle Gordian Knot of Acute Pulmonary Embolism

PERTs Aim to Disentangle Gordian Knot of Acute Pulmonary Embolism

The concept of a rapid response team for acute PE has spread quickly across the United States, although the impact remains unclear. A recently published research letter in CHEST showed that the most common specialties involved... read more

Patient Achieves Remission With CAR-T Cell Therapy for Aggressive Brain Tumors

Patient Achieves Remission With CAR-T Cell Therapy for Aggressive Brain Tumors

A case study published in the December 29 issue of the New England Journal of Medicine outlines the results of a patient treated with his own genetically modified CAR-T cells, using central memory T cells, a stem-cell-like... read more

Triple therapy for influenza with naproxen, clarithromycin, and oseltamavir?

Triple therapy for influenza with naproxen, clarithromycin, and oseltamavir?

Antiviral therapy for influenza is a sore subject. Oseltamavir was initially felt to be a silver bullet. Unfortunately, it turned out that its efficacy was overblown by publication bias. Discordance between guidelines, practice,... read more

Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury

Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury

Therapeutic hypothermia is likely a beneficial treatment following traumatic brain injuries in adults but cannot be recommended in children.... read more

Seizures Prior to Diagnosis of Tuberous Sclerosis Complex

Seizures Prior to Diagnosis of Tuberous Sclerosis Complex

Seizures were a condition commonly experienced by patients prior to diagnosis of TSC; understanding the initial diagnoses experienced by TSC patients may help lead to earlier diagnosis and treatment of TSC. Many patients... read more

Disease Causation Index Established By New Mathematical Model

Disease Causation Index Established By New Mathematical Model

Patients with complex diseases have a higher risk of developing another. Multi-morbidity represents a huge problem in everyday clinical practice, because it makes it more difficult to provide successful treatment. By analysing... read more

Epstein-Barr risk increased by Immune Molecule Deficiency

Epstein-Barr risk increased by Immune Molecule Deficiency

Researchers from the National Institutes of Health National Institute of Allergy and Infectious Diseases, or NIAID, have found a genetic immune disorder causing increased risk and poor control of Epstein-Barr virus and EBV-associated... read more

Clinical challenge in IBD expanded by Systemic inflammation

Clinical challenge in IBD expanded by Systemic inflammation

More targeted antibody therapies carry the potential to transform how physicians treat inflammatory bowel disease. However, management can become less clear when IBD patients present with extra-intestinal manifestations.... read more

Think Sepsis and Act Fast

Think Sepsis and Act Fast

New attention to sepsis including revised definitions, updated guidelines, and new CMS reporting requirements aims to save lives through prevention and prompt and effective management of infections. CDC released a new Vital... read more

How nurses support families of ICU patients towards the end of life

How nurses support families of ICU patients towards the end of life

Researchers gathered evidence on how nurses care for patients and their families in intensive care when life-sustaining treatment is withdrawn. The included studies explored the care of the family before, during and after... read more

Mild electric e-scaffold disrupts bacterial biofilms

Mild electric e-scaffold disrupts bacterial biofilms

Researchers at Washington State University (Spokane, WA, USA) used an e-scaffold made out of conductive carbon fabric and a mild electrical current to produce a low, constant concentration of hydrogen peroxide (H2O2, an effective... read more