Tag: trial
PCSK9 Inhibition and Other New Therapies for Lipid Modification: Good News and Bad
A late-breaking clinical trial session devoted to newly approved and investigational compounds for the treatment of lipids highlighted the end of a once promising therapy for low HDL cholesterol.... read more
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Higher PEEP, lower peak, plateau, and driving pressures, and lower respiratory rate are associated with improved survival from ARDS.... read more
Long-Term Oxygen for COPD with Moderate Desaturation
The prescription of long-term supplemental oxygen did not result in a longer time to death or first hospitalization than no long-term supplemental oxygen in patients with stable COPD.... read more
Glyburide Promising for Treatment of Acute Ischemic Stroke
Although the study did not demonstrate efficacy of glyburide, differences were seen in the amount midline shift at 3-4 days. In the current study, 86 patients with large (82-300 cc) anterior circulation stroke were randomized... read more
Old vs New: End of Debate on Blood Transfusion Storage
The new data come from the Informing Fresh versus Old Red Cell Management (INFORM) trial, which assigned hospitalized patients to receive transfusion of the freshest red cells in the inventory.... read more
Baxter initiates late-stage study of novel therapy for acute kidney injury
Baxter International commences a Phase 3 clinical trial assessing an investigational drug, Prismocitrate 18, that combines a citrate anticoagulant and renal replacement solution.... read more
Abdominal Aortic Aneurysm Screening
The long-term follow-up of the Western Australian trial of screening for abdominal aortic aneurysms (AAAs) reported in this issue of JAMA Internal Medicine1 is likely the last report from the 4 randomized clinical trials1- 4... read more
Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients
Predicting whether an obese critically ill patient can be successfully extubated may be specially challenging. Several weaning tests have been described but no physiological study has evaluated the weaning test that would... read more
Hospitals embed mental health professionals in the ICU
Pilot programs at several large academic medical centers suggest that integrating psychiatrists and other mental-health professionals into hospital units.... read more
Acute caffeine ingestion does not increase arrhythmias in patients with chronic systolic heart failure
Acute ingestion of caffeine did not increase the risk of ventricular or supraventricular arrhythmias as compared to placebo in patients with chronic systolic heart failure, either at rest or during a symptom-limited exercise... read more
Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome
In sepsis-associated ARDS, hydrocortisone treatment was associated with a significant improvement in pulmonary physiology, but without a significant survival benefit.... read more
Blood products and procoagulants in traumatic bleeding
A host of preclinical and clinical studies have evaluated blood product availability and efficacy in trauma. Recently published randomized controlled trials have investigated the ratio of platelet:plasma:red cell transfusion... read more
Palliative-care boosts heart failure patient outcomes
Adding palliative care interventions to management of patients with advanced heart failure improved quality-of-life measures in two relatively small, controlled studies.... read more
More NOAC Comparisons See More Bleeding With Rivaroxaban: Is the ‘Writing on the Wall’?
Evidence is mounting, albeit from observational studies, that while all of the non-vitamin K antagonist oral anticoagulants (NOACs) appear to have similar efficacy in terms of stroke reduction in atrial fibrillation, they... read more
Levosimendan Doesn’t Prevent Acute Organ Dysfunction
For adults with sepsis, levosimendan does not prevent acute organ dysfunction.... read more
Conservative oxygen treatment linked to lower ICU mortality
A conservative protocol for oxygen therapy results in lower intensive care unit (ICU) mortality compared to conventional care.... read more
New HIV treatment appears to have fully erased the virus from a patient's blood
A pioneering new trial offers new hope in the fight against HIV after a patient treated with a new therapy appears to have no trace of the virus in their blood.... read more
