Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with ARDS

Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with ARDS

An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome.... read more

Bi-level Ventilation: Who Needs it and Who Doesn't?

Bi-level Ventilation: Who Needs it and Who Doesn't?

Bi-level ventilation is commonly used in patients with respiratory failure in the emergency department. This is a brief review of the indications for bi-level ventilation as well as a review of the complications of this popular... read more

PaCO2 Equation

PaCO2 Equation

I've previously written about the alveolar gas equation and oxygen delivery equation, both of which deal with the physiologic process of oxygenation. Now I want to discuss the important relationship between alveolar... read more

Identifying barriers to delivering the ABCDE bundle to minimize adverse outcomes for mechanically ventilated patients

Identifying barriers to delivering the ABCDE bundle to minimize adverse outcomes for mechanically ventilated patients

Improved outcomes are associated with the Awakening, Breathing Coordination, Delirium and Early mobility/exercise (ABCDE) bundle; however, implementation issues are common. As yet, no study has integrated the barriers to... read more

Extra Corporeal Carbon Dioxide Removal

Extra Corporeal Carbon Dioxide Removal

In patients with chronic obstructive airway disease and hypercapneic acidosis, who are failing non-invasive ventilation, does extra corporeal carbon dioxide removal compared to non-invasive ventilation alone, reduce the... read more

The impact of oral care on oral health status and prevention of VAP in critically ill patients

The impact of oral care on oral health status and prevention of VAP in critically ill patients

Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections which increase mortality rate and length stay of hospitalization. Oral care would not only improve patient’s oral health and well-being,... read more

Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic tool for H1N1... read more

Rocketamine vs. Keturonium for Rapid Sequence Intubation

Rocketamine vs. Keturonium for Rapid Sequence Intubation

Airway management is a detail-oriented sport. Minor nuances of patient positioning can be essential. Or gentle laryngeal manipulation. Apneic oxygenation can improve first-pass success. Placing the pulse oximeter on the... read more

Systemic and Microcirculatory Effects of Blood Transfusion in Experimental Hemorrhagic Shock

Systemic and Microcirculatory Effects of Blood Transfusion in Experimental Hemorrhagic Shock

The microvascular reperfusion injury after retransfusion has not been completely characterized. Specifically, the question of heterogeneity among different microvascular beds needs to be addressed. In addition, the identification... read more

Hemodialysis and Survival in Intubated Salicylate-Poisoned Patients

Hemodialysis and Survival in Intubated Salicylate-Poisoned Patients

Salicylate-poisoned patients can be incredibly complex and severely ill. Secondary to the significant acid-base abnormalities that can accompany salicylate poisoning, hemodialysis (HD) is sometimes required to facilitate... read more

Post Intubation Hypotension: The AH SHITE mnemonic

Post Intubation Hypotension: The AH SHITE mnemonic

Here is a crowd sourced approach that will allow most etiologies of post intubation hypotension to be identified: The AH SHITE mnemonic is something that you can quickly run through en route to the patient’s room, or at... read more

Antipyretic Therapy in Critically Ill Septic Patients

Antipyretic Therapy in Critically Ill Septic Patients

This meta-analysis aimed to examine the impact of antipyretic therapy on mortality in critically ill septic adults. Inclusion criteria were observational or randomized studies of septic patients, evaluation of antipyretic... read more

Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management

Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management

Spontaneous respiratory effort during mechanical ventilation has long been recognized to improve oxygenation, and because oxygenation is a key management target, such effort may seem beneficial. Also, disuse and loss of peripheral... read more

Comparison of Alveolar Recruitment Strategies for Preventing Postoperative Pulmonary Complications

Comparison of Alveolar Recruitment Strategies for Preventing Postoperative Pulmonary Complications

This randomized clinical trial compares the effects of adding an intensive vs moderate alveolar recruitment strategy to protective ventilation on the number and severity of pulmonary complications following cardiac surgery.... read more

Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation

Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation

Fluid loading is usually the first step in the resuscitation of patients with acute circulatory failure. Fluid responsiveness is defined as the ability of the left ventricle to increase its stroke volume in response to fluid... read more

Mechanical Ventilation: Which Patients Benefit from High PEEP?

Mechanical Ventilation: Which Patients Benefit from High PEEP?

Among patients with hypoxaemia after cardiac surgery, the use of an intensive alveolar recruitment strategy compared with a moderate recruitment strategy resulted in less severe pulmonary complications during the hospital... read more

Predicting and measuring fluid responsiveness with echocardiography

Predicting and measuring fluid responsiveness with echocardiography

Echocardiography is an essential tool to predict and measure fluid responsiveness, according to a recent article, which provides a practical guide. Ashley Miller and Justin Mandeville outline the physiological basis of fluid... read more