Current American College of Cardiology and American Heart Association guidelines state that troponin is the preferred biomarker for diagnosing acute myocardial infarction (MI). Troponin T (TnT) and I molecules have amino acid sequences that are found only in cardiac tissue, making their assays highly specific for detecting cardiac damage. The newer troponin assays are a marvel of modern medicine. Refinements in troponin assays now demand refinements in our clinical reasoning. Newer assays with improved analytical sensitivity will not likely alter the false positive rate.

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