A hospital-wide intervention replacing ceftriaxone with cefotaxime to reduce rate of HAI in the ICU

link.springer.com July 7, 2019

Over the last decades, the incidence of healthcare-associated infections (HAI) caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) involved in poor outcomes has dramatically increased worldwide. This has been explained by the high prevalence of ESBL-PE community carriage and the increasing trend in consumption of antibiotics such as third-generation cephalosporins (3GC). In particular, previous studies have suggested that the high biliary elimination of ceftriaxone (CRO) could increase the selection pressure of 3GC-resistant.