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A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients

ccforum.biomedcentral.com February 6, 2017

Vaccine

This phase II study has shown that IC43 vaccination of ventilated ICU patients produced a significant immunogenic effect. P. aeruginosa infection rates did not differ significantly between groups. In the absence of any difference in immune response following administration of 100 μg IC43 without adjuvant compared with 200 μg IC43 with adjuvant, the 100 μg dose without adjuvant was considered for further testing of its possible benefit of improved outcomes. There were no safety or mortality concerns.

infection mortality study vaccination ventilation

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