Daptomycin is an antimicrobial agent with activity against gram-positive bacteria that is usually reserved for severe infections. Acute eosinophilic pneumonia (AEP) is an increasingly rare side effect that can manifest after its use.

Our patient is a 79-year-old male who was admitted for a left total knee arthroplasty infection.

After daptomycin was started, he developed AEP.

The offending agent was stopped, the appropriate medical treatment was given, and his symptoms significantly improved.

This case illustrates an uncommon side effect of daptomycin.

Prompt medical recognition is paramount for medication discontinuation and adequate medical care.

AEP remains a rare and underknown adverse reaction after daptomycin therapy.

Elderly patients with chronic kidney disease and receiving high doses are, particularly at risk. Our case illustrates the importance of a high index of suspicion for early recognition of this side effect, especially in at-risk patient populations.

It is imperative for clinicians to be familiarized with the condition in order to rapidly recognize its presentation and treat it appropriately.

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