This systematic review highlights the advantages of anesthetic sedation strategies, particularly the use of dexmedetomidine, methadone, or sequential sedation protocols, in improving weaning outcomes, enhancing sedation quality, reducing delirium, and potentially lowering ICU-related costs.

The adoption of these strategies in ICU sedation protocols can significantly enhance the quality of patient care and the efficiency of resource utilization, underscoring the importance of evidence-based sedation management.

Mechanical ventilation is a critical component of care in ICUs, yet its prolonged use can result in significant complications.

Effective sedation strategies play a pivotal role in facilitating the discontinuation of mechanical ventilation and minimizing associated adverse outcomes.

This systematic review evaluates the impact of anesthetic-based sedation methods on optimizing the process of weaning adult patients from mechanical ventilation in intensive care settings.

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