Penicillium Marneffei (PM) infections often present with nonspecific clinical manifestations, and severe respiratory failure (ARF) after infection is particularly uncommon.

This case report a patient who developed severe respiratory failure due to PM infection post-kidney transplantation.

Additionally, it delves into pertinent treatment measures and nursing strategies.

The patient was diagnosed with PM infection, respiratory failure, and post-kidney transplant status.

The treatment measures included the drug therapy and dynamic adjustment the application of nitric oxide combined with ECMO-prone position ventilation, balancing bleeding and thrombosis risks, early enteral nutrition and adaptive progression to pulmonary rehabilitation exercises.

This case is a valuable reference for critical care in similar conditions.

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