Association Between mRNA Expression of CD74 and IL10 and Risk of ICU-acquired Infections

ncbi.nlm.nih.gov September 8, 2017

Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs and mortality. To date, no biomarker has shown sufficient evidence and ease of application in clinical routine for the identification of patients at risk of IAI. Our results suggest that two immune biomarkers, CD74 and IL10, could be relevant tools for the identification of IAI risk in ICU patients. A total of 725 patients were analyzed. At least one IAI episode occurred in 137 patients (19%).