Fluid overload in acute respiratory distress syndrome is associated with increased mortality. The purpose of this study was to investigate the association of cumulative fluid balance (CFB) during the first 7 days of eno-venous extracorporeal membrane oxygenation (VV ECMO) and mortality.

Adult patients on VV ECMO for greater than 168 hours, between November 2015 and October 2019, were included.

CFB during the first 7 ECMO days was compared between survivors and nonsurvivors, and survival was analyzed using Kaplan-Meier analysis and cox proportional hazards modeling.

146 patients were included.

Median age was 45 years, respiratory ECMO survival prediction score was 3, and P/F ratio was 70.

CFB for ECMO days 1–3 was +2,350 cc, days 4–7 –3,070 cc, and days 1–7 –341 cc.

117 patients (80%) survived to hospital discharge.

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