An autopsy-based study of 11 people who died from COVID-19 shows a mismatch between viral hotspots in the body and sites of inflammation and organ damage, suggesting that immune responses, rather than the virus itself, are responsible for death.

Numerous studies have suggested that the immune system contributes to the organ damage seen in some severe cases of COVID-19. Christopher Lucas and David Dorward at the University of Edinburgh, UK, and their colleagues conducted detailed autopsies to map signs of SARS-CoV-2 in the body, along with sites of inflammation and injury.

The survey of 37 anatomical sites, including the lungs, found little correlation between levels of the virus and inflammation: some tissues harboured the virus but were not inflamed, whereas others were damaged but did not contain high levels of SARS-CoV-2. The findings have not yet been peer reviewed.

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