Benefits and harms of duloxetine for treatment of stress urinary incontinence

cmaj.ca February 7, 2017

Duloxetine was significantly better than placebo in terms of percentage change in weekly incontinence episodes (mean difference – 13.56%, 95% confidence interval [CI] -21.59% to -5.53%) and change in Incontinence Quality of Life total score (mean difference 3.24, 95% CI 2.00 to 4.48). However, the effect sizes were small, and a sensitivity analysis (with removal of one trial) showed that the number needed to treat for a Patient Global Impression of Improvement rating of "much better or very much better" was 8 (95% CI 6 to 13).