Beyond SOFA: Sepsis ImmunoScore Redefines Risk Stratification for Mortality and ICU Admission

medrxiv.org October 8, 2025

This multicenter observational study involving over 6,000 adult patients found that the Sepsis ImmunoScore, an AI-based tool, significantly outperformed six conventional clinical scores and biomarkers in predicting sepsis, in-hospital mortality, and ICU admission.

The study compared the ImmunoScore to widely used metrics like SOFA, qSOFA, NEWS, SIRS, procalcitonin (PCT), and C-reactive protein (CRP).

The ImmunoScore demonstrated statistically significant superior predictive accuracy across all three outcomes.

The Sepsis ImmunoScore offers a substantial improvement over current methods for risk stratification in patients with suspected infection. Its enhanced accuracy suggests it could significantly improve clinical decision-making, potentially leading to more timely interventions and better outcomes for patients with sepsis.