Postoperative blood glucose levels significantly impact outcomes in cardiac surgery patients undergoing extracorporeal circulation (ECC) auxiliary to open heart surgery.

The study’s primary outcome was the 90-day mortality, and the duration of hospital and ICU stays were considered secondary outcomes.

Kaplan-Meier survival analysis, Multivariate Cox regression models, smooth curve fitting, Restricted Cubic Spline (RCS) curve, and subgroup analyses were conducted to evaluate the relationship between blood glucose levels and patient outcomes.

Higher blood glucose levels were significantly related to increased 90-day mortality.

The analysis revealed the nonlinear relation between blood glucose and 90 days mortality, with an inflection point at 119 mg/dL (P<0.05). Patients with blood glucose levels above this threshold had a markedly higher risk of mortality. Additionally, elevated blood glucose was associated with prolonged hospitalization and ICU stays. Elevated perioperative postoperative blood glucose values were related to an increased 90-day mortality in patients who underwent ECC. When blood glucose levels exceeded 119 mg/dL, it increased the patient's 90-day risk of death. When blood glucose levels exceeded 119 mg/dL, blood glucose levels were positively associated with 90-day postoperative mortality.

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