Cardiac Damage in Patients Infected with Different COVID-19 Variants of Concern

mdpi.com December 19, 2024

Coronavirus Disease 2019 causes significant morbidity, and different variants of concern (VOCs) can impact organ systems differently.

We conducted a single-center retrospective cohort analysis comparing biomarkers and clinical outcomes in hospitalized patients infected with the wild-type or Alpha (wt/Alpha) VOC against patients infected with the Omicron VOC.

We included 428 patients infected with the wt/Alpha VOC and 117 patients infected with the Omicron VOC.

The Omicron cohort had higher maximal median high-sensitivity Troponin-T (hs-TnT) levels (wt/Alpha: 12.8 ng/L, IQR 6.6–29.5 vs. Omicron: 27.8 ng/L, IQR 13.7–54.0; p < 0.001) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (wt/Alpha: 256 ng/L, IQR 74.5–913.5 vs. Omicron: 825 ng/L, IQR 168–2759; p < 0.001) levels.