Circulating Biomarkers May be Unable to Detect Infection at the Early Phase of Sepsis in ICU Patients

link.springer.com September 17, 2018

During the study period, 363 patients with SIRS were screened, 84 having exclusion criteria. Ninety‑one patients were classiﬁed as having non‑septic SIRS and 188 as having sepsis. Eight biomarkers had an area under the receiver operating curve (ROC‑AUC) over 0.6 with a 95% conﬁdence interval over 0.5. LASSO regression identiﬁed CRP and HLA‑DRA mRNA as being repeatedly associated with sepsis, and no model performed better than CRP alone. The CAPTAIN study was a prospective observational multicenter cohort of 279 ICU patients with hypo‑ or hyperthermia and criteria of SIRS, included at the time the attending physician considered antimicrobial therapy. Investigators collected blood at inclusion to measure 29 plasma compounds and ten whole blood RNAs, and—for those patients included within working hours—14 leukocyte surface markers.