Static echocardiographic variables did not reliably reflect the volume state as defined by estimates of mean systemic filling pressure. There was no statistical or clinically robust relationship between static echocardiographic variables of cardiac systolic function and global heart efficiency.

Echocardiography remains valuable in estimating volume state by the ability to measure cardiac output for the calculation of analogue mean systemic filling pressure.

This observational study did not demonstrate a “robust” relationship between estimates of mean systemic filling pressure and static echocardiographic variables used in clinical practice to estimate volume status or between estimates of global heart efficiency and echocardiographic measurement of cardiac systolic function.

These relationships were characterised by high indices of bias and imprecision between volume status estimates and moderate to weak correlations between cardiac performance indices.

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