Convalescent Plasma Cuts Death by 10% in COVID Patients on Mechanical Ventilation

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A randomized clinical trial in Belgium finds that convalescent plasma reduces death rates by about 10% in COVID-19 patients requiring invasive mechanical ventilation.

University of Liege researchers led the open-label study involving 17 intensive care units (ICUs) in Belgium from October 2020 to March 2022, largely pre-Omicron strain. The results were published today in the New England Journal of Medicine.

A total of 475 COVID-19 patients with acute respiratory distress syndrome (ARDS) were enrolled in the study, with 237 receiving convalescent plasma within 5 days after initiation of mechanical ventilation and 238 receiving standard care.

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