Copeptin is an independent marker of severity of the post cardiac arrest syndrome, partially related to circulatory failure.

690 patients were included in the analyses, of whom 203 (30.3%) developed cardiovascular deterioration within 24 h, and 273 (39.6%) died within 30 days.

Serial blood samples were collected at 24, 48, and 72 h as part of the target temperature management at 33 °C versus 36 °C after cardiac arrest trial, an international multicenter randomized trial where unconscious survivors after out-of-hospital cardiac arrest were allocated to an intervention of 33 or 36 °C for 24 h.

The main findings of this sub-study of the TTM trial were that copeptin is a time sensitive, independent predictor of early mortality after OHCA, weakly associated with cardiovascular failure.

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