Protein C was superior for the prediction of organ dysfunction after 7 days of ICU treatment when compared with other biomarkers of endothelial function, inflammation, and coagulation. C-reactive protein (CRP) and white blood cells (WBC) did not significantly differ in accordance with the severity of organ dysfunction, especially within the first 3 days.

Endothelial biomarkers (soluble thrombomodulin, plasminogen activator inhibitor-1, and protein C) and markers of inflammation and coagulation were evaluated during the ICU stay. Sequential Organ Failure Assessment scores were assessed for 7 days after ICU admission to determine organ dysfunction.

The patients were divided into 5 stratified groups: Sequential Organ Failure Assessment, Sequential Organ Failure Assessment, Sequential Organ Failure Assessment, Sequential Organ Failure Assessment, and Sequential Organ Failure Assessment.

Read More