Vaccines are highly effective in preventing COVID-19 hospitalisations and deaths. COVID-19-related deaths in fully vaccinated individuals have, however, been reported.

To inform public health strategy and vaccination policy, it is vital to characterise these post-vaccination COVID-19 fatalities.

We used EAVE II, a national, individual-level surveillance system, to estimate the frequency of COVID-19-related deaths among fully vaccinated individuals and to describe the clinical and demographic characteristics of COVID-19-related deaths among fully vaccinated individuals since the start of the COVID-19 vaccination programme in Scotland.

We also conducted survival analyses to understand predictors for death among fully vaccinated individuals who tested positive for SARS-CoV-2.

Ethical approval was granted by the National Research Ethics Service Committee, Southeast Scotland 02 (12/SS/0201).

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