Race is a social construct. It is used in medical diagnostic algorithms to adjust the readout for spirometry and other diagnostic tests.

The authors review historic evidence about the origins of race adjustment in spirometry, and recent attention to the lack of scientific evidence for their continued use.

Existing reference values imply that White patients have better lung function than non-White patients.

They perpetuate the historical assumptions that human biological functions of the lung should be calculated differently on the basis of racial-skin color without considering the difficulty of using self-identified race.

More importantly, they fail to consider the important effects of environmental exposures, socioeconomic differences, health care access, and prenatal factors on lung function.

In addition, the use of “race adjustment” implies a White standard to which other non-White values need “adjustment.”

Because of the spirometric guidelines in place, the current diagnostic prediction adjustment practice may have untoward effects on patients not categorized as “White,” including underdiagnosis in asthma and restrictive lung disease, undertreatment with lung transplant, undercompensation in workers compensation cases, and other unintended consequences.

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