Venous congestion is a pathophysiological state where high venous pressures cause organ edema and dysfunction. Venous congestion is associated with worse outcomes, particularly acute kidney injury (AKI), for critically ill patients.

Venous congestion can be measured by Doppler ultrasound at the bedside through interrogation of the inferior vena cava (IVC), hepatic vein (HV), portal vein (PV) and intra-renal veins (IRV).

The objective of this study is to quantify the association between Doppler identified venous congestion and the need for renal replacement therapy (RRT) or death for patients with septic shock.

This study is a pre-specified sub-study of the ANDROMEDA-SHOCK 2 (AS-2) randomized control trial (RCT) assessing hemodynamic resuscitation in septic shock and will enroll at least 350 patients across multiple sites.

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