The present data indicate that heart rate variability (HRV) analysis could be useful for early prognostication for comatose patients during hypothermic TTM within 24 h after ROSC.

The value of HRV as a prognosticator of poor outcome should be confirmed in a larger study.

66 patients were recruited and allocated to the good or poor outcome groups.

Of the 20 HRV-related variables, ln very-low frequency (ln VLF) power, detrended fluctuation analysis (DFA) (α1), and multiscale entropy (MSE) index significantly differed between the groups, with a statistically significant odds ratio (OR) by univariate logistic regression analysis.

Between January 2015 and December 2017, adult patients with out-of-hospital sudden cardiac arrest, successfully resuscitated in the emergency department and admitted to the ICU of the Niigata University in Japan, were prospectively included.

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