Traumatic brain injury (TBI), also known as the “Silent Epidemic,” is a growing devastating global health problem estimated to affect millions of individuals yearly worldwide with little public recognition, leading to many individuals living with a TBI-related disability.

TBI has been associated with up to five times increase in the risk of dementia among multiple neurologic complications compared with the general population. Several therapies, including statins, have been tried and showed promising benefits for TBI patients.

In this systematic review, we evaluated the recent literature that tested the role of statins on neurological and cognitive outcomes such as Alzheimer’s Disease and non-Alzheimer’s dementia in survivors of TBI with various severities.

We conducted a systematic search on PubMed, PubMed Central, MEDLINE, and Google Scholar.

MeSH terms and keywords were used to search for full-text randomized clinical trials (RCTs), cross-sectional, case-control, cohort studies, systematic reviews, and animal studies published in English.

Inclusion and exclusion criteria were applied, and the articles were subjected to quality appraisal by two reviewers.

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