The combined toxicity of amlodipine and metformin is a rarely reported phenomenon in the literature. The management varies depending on the clinical status of the patient.

We present a case that was managed successfully with the early initiation of hemodialysis.

Introducing emergency dialysis will lead to significant outcomes in mortality and morbidity in patients with combined toxicity of amlodipine and metformin.

Moreover, non-ST elevation myocardial infarction is also expected to be seen in such patients, which occurs as an outcome of amlodipine-mediated vasodilation.

Therefore, there is a dire need for monitoring and managing cardiac complications as well.

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