Critically ill patients managed with the Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility bundle spent three more days breathing without assistance, experienced less delirium, and were more likely to be mobilized during their ICU stay than patients treated with usual care.

For mechanically ventilated patients (n = 187), we examined the association between bundle implementation and ventilator-free days.

For all patients, we used regression models to quantify the relationship between Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility bundle implementation and the prevalence/duration of delirium and coma, early mobilization, mortality, time to discharge, and change in residence.

Safety outcomes and bundle adherence were monitored.

Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility bundle.

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