While the primary outcome of Day 7 survival was greater in patients randomized to ketamine, there was no significant difference in survival by Day 28.

A prospective, randomized, open-label, parallel assignment, single-center clinical trial performed by an anesthesiology-based Airway Team under emergent circumstances at one high-volume medical center in the United States.

Of the 801 enrolled patients, 396 were analyzed in the etomidate arm, and 395 in the ketamine arm.

Day 7 survival was significantly lower in the etomidate arm than in the ketamine arm.

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