Vitamin C monotherapy failed to significantly reduce mortality in septic shock patients as hypothesized. Our findings do not support its routine clinical use for this purpose.

Of 124 subjects receiving study drug and included in analysis, 60 received vitamin C and 64 placebo.

The primary outcome of all-cause 28-day mortality was lower in the vitamin C arm but did not reach statistical significance.

Initiation of renal replacement therapy (RRT) was higher in the vitamin C arm, as was volume of fluid administration within 6 hours of study drug initiation.

There were no statistically significant differences in other secondary outcomes.

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