Finding a New Way to Fight Late-stage Sepsis by Boosting Cells’ Antibacterial Properties
phys.orgResearchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body’s extreme reaction to infection.
The scientists used nanotechnology to transform donated healthy immune cells into a drug with enhanced power to kill bacteria.
In experiments treating mice with sepsis, the engineered immune cells eliminated bacteria in blood and major organs, dramatically improving survival rates.
This work focuses on a treatment for late-stage sepsis, when the immune system is compromised and unable to clear invading bacteria.
The scientists are collaborating with clinicians specializing in sepsis treatment to accelerate the drug-development process.