In-hospital renal replacement therapy (RRT) is widely used for the treatments of acute kidney injury (AKI) in crush injury (CI) victims. This study was designed to investigate whether preventive peritoneal dialysis (PPD) is useful for renal protection in CI.

PPD attenuated lactic acidosis and reduced serum K+ and myoglobin levels in CI animals. In addition, PPD was effective in removing blood urea nitrogen (BUN) and creatinine, and reduced renal expressions of neutrophil gelatinase-associated lipocalin (NGAL).

The combination of PPD and MFR further attenuated AKI with significantly decreased histological scores and reduced NGAL expressions as compared with the MFR group.

The use of PPD at the onset of compression release is beneficial for renal protection and survival outcome in a rabbit model of CI.

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