This study presents the first evidence that full vaccination against COVID-19 suppresses emergent mutations of SARS-CoV-2 delta variants. An evolution algorithm, Tajima’s D test with a threshold value as -2.50, can provide a promising tool to forecast new COVID-19 outbreaks.

Full vaccination against COVID-19 is critical to suppress emergent mutations. Tajima’s D test score, with a threshold value as -2.50, can provide a promising tool to forecast new COVID-19 outbreaks.

The vaccination coverage rate is inversely correlated to the mutation frequency of the SARS-CoV-2 delta variants in 16 countries of 20 countries studied.

We also discovered delta variants evolved differently under the positive selection pressure in the United Kingdom and India.

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