This comprehensive study highlights the importance of utilizing the MR-pheWAS framework in unraveling the complex etiology and pathogenesis of ARDS, and further underlines the value of integrating blood-based biomarkers into the basic model in enhancing the precision of ARDS risk prediction.

These findings have significant implications for risk assessment, early detection, and potential guidance of therapeutic strategies in the management of ARDS.

Phenome-wide association studies and subsequent multi-omics investigations provide novel biomarkers involving acute respiratory distress syndrome (ARDS).

These findings present a promising prediction model with potential clinical utility, enhancing early clinical management and intervention strategies for ARDS development.

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