This study demonstrated the positive effect of a behavioral strategy based on the IMB model in improving noninvasive ventilation (NIV) adherence in patients with chronic hypercapnic respiratory failure (CHRF).

The extended benefits of the IMB-NIV program for sleep quality, HRQoL, and ED service use, along with the high fidelity of the hybrid approach, suggest its efficacy to enhance CHRF management.

Future studies should evaluate its effects on ventilator parameters and validate its overall clinical effectiveness and cost-effectiveness.

This randomized clinical trial with 124 patients found that the information-motivation-behavioral program (IMB-NIV) significantly improved NIV adherence, sleep quality, and CHRF-specific quality of life and reduced emergency department utilization in patients with CHRF, with effects sustained up to the 12-month follow-up.

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