This study indicate that hyperoxemia is not associated with increased 28-day mortality compared to normoxemia. Nonetheless, both moderate and severe hyperoxemia are frequently detected in trauma patients, with severe hyperoxemia exhibiting a tendency towards prolonged hospital stays compared to normoxaemia patients.

Given the retrospective nature of our study, comprehensive randomized controlled trials are essential to fully assess the potential correlation between hyperoxemia and outcomes in trauma patients.

In this retrospective multicentre cohort study of 1,189 severely injured patients in Switzerland, both hypoxaemia and hyperoxaemia were frequently observed upon hospital admission.

Hyperoxemia was not associated with an increased 28-day mortality when compared to normoxemia. However, the presence of severe hyperoxemia showed a tendency with an extended hospital stay compared to normoxemia patients.

While the detrimental effects of hypoxaemia are well recognized, the potential risks of hyperoxemia have received less attention in previous research. Although prior studies have reported hyperoxemia as a common occurrence in trauma patients, a finding in line with our data, its impact on patient outcomes remains insufficiently investigated.

This study revealed that patients with severe hyperoxemia had prolonged stays both in hospital and in the ICU compared to normoxemic patients.

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