Conventional beta-lactam dosing is flawed in critically ill patients. Useful tools such as the MeroRisk Calculator need to be comprehensively evaluated clinically, and if successful should be added into clinical practice to guide effective antibiotic dosing. Mortality due to severe infections in the intensive care unit (ICU) remains high despite recent therapeutic advancements. However, appropriate antibiotic administration (including spectrum of activity and therapeutic exposure) is rarely a straightforward process in ICU patients as they commonly develop extreme pathophysiological changes that can alter antibiotic pharmacokinetics and consequently affect drug exposure in this population.

Read More