This study aimed to assess the prognostic value of an array of biomarkers regarding the likelihood of a lethal outcome in critically ill COVID-19 patients.

We took advantage of the opportunity to classify them into immune cell-based and albumin-based parameters with a reasonable turnaround time in a critical care setting.

The only independent predictor of lethal outcomes at ICU admission is the albumin-based LDH/ALB ratio.

Most of the other parameters were moderate, although highly significant predictors of mortality in critically ill COVID-19 patients: levels of LLR, N/LP, NLR, LDH, IL-6, and D-dimer higher than cut-off values are moderate predictors of lethal outcomes.

612 adult critically ill COVID-19 patients admitted to the intensive care unit (ICU) between April 2020 and November 2022.

Blood measurement on admission to the ICU encompassed complete blood count (CBC), IL-6, C-reactive protein (CRP), albumin, lactate, lactate dehydrogenase (LDH), serum bicarbonate, arterial base deficit/excess (BD/E), and D-dimer.

All the measured and calculated parameters were compared between survivors and non-survivors, with the outcome measure being hospital mortality.

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